教授，博士生导师，现任中国遗传学会基因组编辑专业委员会委员，中国生物化学与分子生物学会基因专业委员会委员，上海市生物化学与分子生物学会常务委员，中科院分子细胞科学卓越创新中心客座研究员。主要研究方向是DNA修复与基因编辑，已在Nature Biotechnology、Nature Structural & Molecular Biology、Cell Research、Genome Biology等国际知名刊物发表通讯作者论文，受到到Cell、Science等杂志的采访报道。获2019年上海市生物化学与分子生物学会青年新锐奖，国家自然科学基金优秀青年基金、上海市浦江人才计划支持，目前已主持国家级省部级项目5项，申请PCT国际发明专利6项、中国专利3项。先后担任Cell, Science, Nature, Nature Reviews Molecular Cell Biology, Nature Biotechnology, Nat Cell Biology, Nat Chemical Biology, Cell Stem Cell, Developmental Cell, Nature Communications等国际知名学术期刊审稿人。
研究方向
DNA修复与基因编辑
学习和工作经历
2002年在南开大学获得生物化学与分子生物学学士学位。2009年在中科院上海生化细胞所获得生物化学与分子生物学博士学位。2009年至2014年在美国国立健康研究院（NIH）进行博士后研究。2014年起在上海科技大学工作。
近期发表论文
1.Li Yang*, Bei Yang* and Jia Chen*. One Prime for All Editing. Cell, 2019, 179: 1448-1450
Ying Wang#, Runze Gao#, Jing Wu#, Yi-Chun Xiong, Jia Wei, Sipin Zhang, Bei Yang, Jia Chen* and Li Yang*. Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs. Genome Biol, 2019, 20: 218-224
Jia Chen*, Bei Yang* and Li Yang*. To BE or not to BE, that is the question. Nat Biotechnol, 2019, 37: 520-522
Bei Yang*, Li Yang* and Jia Chen*. Development and Application of Base Editors. CRISPR J, 2019, 2: 91-104
Jianan Li#, Zhen Liu#, Shisheng Huang#, Xiao Wang, Guanglei Li, Yuting Xu, Wenxia Yu, Shanshan Chen, Yu Zhang, Hanhui Ma, Zunfu Ke, Jia Chen*, Qiang Sun* and Xingxu Huang*. Efficient base editing in G/C-rich regions to model androgen insensitivity syndrome. Cell Res, 2019, 29: 174-176
Xiao Wang#, Jianan Li#, Ying Wang#, Bei Yang#, Jia Wei#, Jing Wu, Ruixuan Wang, Xingxu Huang*, Jia Chen* and Li Yang*. Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion. Nat Biotechnol, 2018, 36: 946-949 (Highlighted by Nicole Rusk, Better base editors. Nat Methods, 2018, 15: 763)
Yanting Zeng#, Jianan Li#, Guanglei Li#, Shisheng Huang, Wenxia Yu, Yu Zhang, Dunjin Chen, Jia Chen, Jianqiao Liu* and Xingxu Huang*. Correction of the Marfan Syndrome pathogenic FBN1 mutation by base editing in human cells and heterozygous embryos. Mol Ther, 2018, 26: 2631-2637
Zhen Liu#, Zongyang Lu#, Guang Yang#, Shisheng Huang, Guanglei Li, Songjie Feng, Yajing Liu, Jianan Li, Wenxia Yu, Yu Zhang, Jia Chen, Qiang Sun* and Xingxu Huang*. Efficient generation of mouse models of human diseases via ABE-and BE-mediated base editing. Nat Commun, 2018, 9: 2338
Wen Jiang#, Songjie Feng#, Shisheng Huang, Wenxia Yu, Guanglei Li, Guang Yang, Yajing Liu, Yu Zhang, Lei Zhang, Yu Hou, Jia Chen, Jieping Chen* and Xingxu Huang*. BE-PLUS: a new base editing tool with broadened editing window and enhanced fidelity. Cell Res, 2018, 28: 855-861
Jia Chen, Weizhi Ji, Prashant Mali and April Pawluk. The Future of Genome Editing. Cell, 2018, 173: 1311-1313
Xiaosa Li#, Ying Wang#, Yajing Liu#, Bei Yang#, Xiao Wang, Jia Wei, Zongyang Lu, Yuxi Zhang, Jing Wu, Xingxu Huang*, Li Yang* and Jia Chen*. Base editing with a cpf1-cytidine deaminase fusion. Nat Biotechnol, 2018, 36: 324-327 (Highlighted in Tools in Brief, Expanding the range of base editors. Nat Methods, 2018, 15:314)
Liqun Lei#, Hongquan Chen#, Wei Xue#, Bei Yang#, Bian Hu#, Jia Wei, Lijie Wang, Yiqiang Cui, Wei Li, Jianying Wang, Lei Yan, Wanjing Shang, Jimin Gao, Jiahao Sha, Min Zhuang, Xingxu Huang, Bin Shen*, Li Yang* and Jia Chen*. APOBEC3 induces mutations during repair of CRISPR–Cas9-generated DNA breaks. Nat Struct Mol Biol, 2018, 25: 45-52
